Abstract
Aim:This study was designed to evaluate the synergistic activities of hydroalcoholic extracts of medicinal plants Origanum vulgare and Hypericum perforatum and their active components, carvacrol and hypericin against Staphylococcus aureus.Methods:The synergistic effects of the plants, as well as carvacrol and hypericin, were examined using a checkered method against S. aureus (ATCC 12600).Results:A fractional inhibitory concentration of 0.5 was obtained for combination of O. vulgare and H. perforatum and 0.49 for combination of the active ingredients carvacrol and hypericin, both of which indicated a synergistic effect.Conclusion:This preliminary evaluation demonstrated a synergistic property of O. vulgare and H. perforatum extracts in treating S. aureus infection. This study indicates that combination of the plants, as well as combination of carvacrol and hypericin, might be used as a new antibacterial strategy against S. aureus.
Highlights
Conclusion & future perspective The present study provided evidence of the antimicrobial and synergistic effects of the combination of hydroalcoholic O. vulgare and H. perforatum extracts, as well as combination of carvacrol and hypericin, on S. aureus infection
We did not examine the possible synergistic effects of the plant extract or their active ingredients with commercial antibacterial agents. If they possess synergistic activity with commercial antibiotics, this could have several beneficial effects for patients. This synergistic activity could enable the reduction of doses of commercial antibiotics, which in turn would reduce their toxic effects
The synergistic effects of H. perforatum and O. vulgare, and carvacrol and hypericin, were examined using a Checkerboard test and AZDAST test against S. aureus
Summary
This study was designed to evaluate the synergistic activities of hydroalcoholic extracts of medicinal plants Origanum vulgare and Hypericum perforatum and their active components, carvacrol and hypericin against Staphylococcus aureus
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
