Abstract
Objective To investigate the expression, relationship and the clinical significance of Cyclin A and p16 protein in hepatocareinogenesis. Methods The expression of Cyclin A and p16 protein in 35 cases of HCC and corresponding non-tumor tissues was detcted by Western blot. CyclinA was as-sessed by immunohistochemistry. Results The over-expression of Cyclin A was found in 21 (60.0%) outof 35 cases of HCC,and the expression loss of p16 protein was found in 22 (62.9%) out of 35 cases. Nineteen cases (90.5%) out of 21 cases with Cyclin A over-expression and 3 (21.4%) out of 14 cases without Cyclin A over-expression turned up the expression loss of p16 protein. There was significant differ-ence between the two groups (P < 0. 05 ). Conclusion The disorder of cell cycle caused by the over-ex- pression of Cyclin A and the expression loss of p16 protein may play important roles and the two factors en-hance each other in the mechanism of hepatocareinogenesis. Key words: Carcinoma,hepatocellular; Cyclin A; p16 protein
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
