Abstract
Objective: to report two cases of resistance to thyroid hormone to increase the awareness of this syndrome, which is frequently isdiagnosed and incorrectly treated. CORRESPONDENCE TO: Methods: we described two siblings, both of whom were diagnosed as having thyrotoxicosis and one of them was treated with carbamazole and subsequently developed hypothyroidism. Both patients showed features of resistance to thyroid hormone and required additional L-thyroxine to normalize the thyroid stimulating hormone level while remaining clinically euthyroid. Results: Laboratory evaluation revealed increased serum thyroxine and tri-iodothyroxine levels as well as increased thyroid stimulating hormone (TSH) levels. The free alpha subunit/TSH ratio was normal, and CT of the pituitary gland showed no tumour. Metabolic studies using graded doses of tri-iodothyroxine supported the diagnosis. 4) Dr. Elamin A, E-mail: azizmin@gmail.com
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
