The syndrome of hyponatremia and renal sodium loss probably resulting from inappropriate secretion of antidiuretic hormone.

Abstract

Case Reports1 December 1959THE SYNDROME OF HYPONATREMIA AND RENAL SODIUM LOSS PROBABLY RESULTING FROM INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONEH. J. ROBERTS, M.D.H. J. ROBERTS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-6-1420 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis paper reports a patient with a bronchogenic carcinoma who developed profound hyponatremia and hypochloremia in association with considerable loss of both sodium and chloride in the urine. Clinically he was found to have normal renal and adrenal function and at autopsy the kidneys and the adrenals showed no significant pathologic change.Two earlier instances of this particular syndrome were included in the report by Schwartz et al. in 1957.1It was the opinion of these investigators that this unusual electrolyte derangement could best be explained by a sustained and inappropriate secretion of antidiuretic hormone, and that this disorder was...Bibliography1. SchwartzBennettCurelopBartter WBWSFC: A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone, Am. J. Med. 23: 529, 1957. CrossrefMedlineGoogle Scholar2. PorterFrantz MRVK: Tumors associated with hypoglycemia—pancreatic and extrapancreatic, Am. J. Med. 21: 944, 1956. CrossrefMedlineGoogle Scholar3. 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BrickGlazer IBL: Marked eosinophilia with cancer: a poor prognostic sign, Ann. Int. Med. 35: 213, 1951. LinkGoogle Scholar9. WeltSeldinNelsonGermanPeters LGDWWPWJJP: Role of central nervous system in metabolism of electrolytes and water, Arch. Int. Med. 90: 355, 1952. CrossrefGoogle Scholar10. Cort JH: Cerebral salt wasting, Lancet 1: 752, 1954. CrossrefGoogle Scholar11. Wise BL: Relation of brain stem to renal electrolyte excretion, Proc. Soc. Exper. Biol. and Med. 91: 557, 1956. CrossrefMedlineGoogle Scholar12. EpsteinLevitin FHH: "Cerebral salt-wasting": an example of sustained inappropriate release of antidiuretic hormone, abstract, J. Clin. Investigation 38: 1001, 1959. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: West Palm Beach, Florida*Received for publication August 18, 1958.Requests for reprints should be addressed to H. J. Roberts, M.D., 1525 North Flagler Drive, West Palm Beach, Florida. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLung Cancer MarkersPituitary insufficiency, inappropriate antidiuretic hormone (ADH) secretion, and carcinoma of the bronchusParaneoplastic syndromes Resulting from elaboration of ectopic hormones, antigens and bizarre toxinsAuswirkungen der renalen Insuffizienz auf die Zusammensetzung der Cerebrospinalflüssigkeit, den Stoffwechsel des ZNS und zentralnervöse FunktionenDie zentralnervöse klinische Symptomatologie der akuten und chronischen NiereninsuffizienzStörungen der HarnkonzentrierungHormonal Syndromes Associated with NeoplasiaCase 30-1967The syndrome of inappropriate secretion of antidiuretic hormoneAn investigation into the cause of hyponatremia in the syndrome of inappropriate secretion of antidiuretic hormoneInappropriate Renal Sodium Loss Reverted by Vena Cava ObstructionHENRY O. HEINEMANN, M.D., JOHN H. LARAGH, M.D., F.A.C.P.Hyponatremia from inappropriate antidiuretic hormone elaboration in carcinoma of the lungPARANEOPLASTIC DISORDERS“Inappropriate” secretion of antidiuretic hormone without corresponding hyponatraemia in cerebral pathologyHypoadrenocorticotropism with Hyponatremia, Resembling Antidiuretic Hormone ExcessJOSEPH L. GRANT, M.D., F.A.C.P., ALASTAIR MACDONALD, STEPHEN R. BROVENDER, M.D., NICHOLAS YANKOPOULOS, M.D.Physiology of the kidneyDisorders of renal functionBronchogenic Carcinoma with Inappropriate Antidiuretic Activity in Plasma and TumorA review of unusual systemic manifestations associated with carcinomaCarcinoma of the Lung with Inappropriate AntidiuresisHyponatremia and the inappropriate secretion of antidiuretic hormoneHyponatremia and bronchogenic carcinoma associated with renal excretion of large amounts of antidiuretic materialElectrolyte disturbances associated with cancerHYPONATREMIA IN ACUTE INTERMITTENT PORPHYRIA PROBABLY RESULTING FROM INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONE*Use of a low-sodium formula as an improved Karell diet, with emphasis upon the outpatient management of heart failure and lymphedemaAldosterone in Cerebral Salt WastingThe Clinical and Physiologic Significance of the Serum Sodium ConcentrationUnstable osmolar homeostasis with and without renal sodium wastageIdiopathic, episodic inappropriate secretion of antidiuretic hormoneAbnormal electrolyte and water metabolism in acute intermittent porphyriaHypo- and HypernatremiaLOUIS G. WELT, M.D., F.A.C.P.Cerebral HyponatremiaSodium BalanceHyponatremia and Renal Wasting of Sodium in Patients with Malfunction of the Central Nervous System 1 December 1959Volume 51, Issue 6Page: 1420-1426KeywordsAntidiuretic hormoneAutopsyBlood plasmaBradycardiaChloridesHyponatremiaKidneysPathogenesisSodiumUrine ePublished: 1 December 2008 Issue Published: 1 December 1959 PDF downloadLoading ...