Abstract
BackgroundEsophageal squamous cell carcinoma is a relative common malignancy with a very poor prognosis, even adopting an integrated and multidisciplinary approach. According to the literature, gastrointestinal stromal tumors (GISTs) rarely originate from the esophagus. Moreover there are not reports of synchronous occurrence of squamous cell carcinoma and GIST at esophageal site.Case presentationWe describe a case of a 74 year old patient who underwent surgery for squamous cell carcinoma of the lower third of the esophagus with an incidental pathologic diagnosis of a concomitant GIST in the thoracic tract.ConclusionIn literature there is no evidence of concomitant squamous carcinoma and GIST of the thoracic esophagus, even if esophageal GISTs are sometimes described. The occasional finding of this neoplastic lesion underlines the importance of a carefully pathological diagnosis for its identification. Surgery, followed by a multidisciplinary approach remains the first-line treatment in both squamous and stromal neoplasm.
Highlights
Esophageal squamous cell carcinoma is a relative common malignancy with a very poor prognosis, even adopting an integrated and multidisciplinary approach
The majority of esophageal gastrointestinal stromal tumors (GISTs) arise at the gastro-esophageal junction; a GIST located at the level of the thoracic esophagus is extremely rare
Many esophageal GISTs are diagnosed after the onset of clinical symptoms, or sometimes discovered by chance, during routine examinations
Summary
Our case report seems to be the only one described in a patient with a myeloproliferative syndrome, esophageal squamous cell carcinoma and GIST. The occasional finding of this latter neoplastic lesion underlines once more the importance of a carefully pathological diagnosis and a multidisciplinary approach. Surgery [19,20] remains the first-line treatment in both squamous and stromal neoplasms. Written consent was obtained from the patient for publication of this case report
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