The Sweet and Sour Taste of Phosphoinositide Signaling: Protonation of PI4P Modulates Its Function in Response to Cytoplasmic pH Changes.

Abstract

Phosphoinositides are signaling lipids that recruit effector proteins to membranes. Shin etal. show that a glucose-starvation-induced drop in cytosolic pH alters the protonation state of the phosphoinositide PI4P, resulting in dissociation of its effector Osh1 from the trans-Golgi network membrane and metabolic regulation of lipid and protein sorting.