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Abstract
Although a variety of properties which characterize virus-transformed animal cells (e.g., morphological changes, loss of growth control, agglutination by plant lectins) have been linked to surface membrane alterations (Black et al., 1971), perhaps the most important surface alteration which occurs in the transformed cell is that involving antigenic changes, since the definitive feature of the neoplastic cell is the ability to produce a tumor in an appropriate host. Whether a transformed cell will produce a tumor in the autochthonous or syngeneic host involves many factors, but of great significance is the presence of “new” surface membrane antigens associated with the transformation process and the immunological response they evoke.KeywordsSialic AcidSurface AntigenSimian VirusPolyoma VirusTransplantation AntigenThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Published Version
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