Abstract
Mouthwashes containing Candida albicans in spore and hyphal forms were administered to eight healthy, non-Candida-carrying volunteers and the clearance rates were measured by saliva counts and imprint cultures of the oral mucosal surfaces. Neither the use of spore or hyphal forms, nor varying the number of C. albicans in the mouthwash, from 8 × 10 3 to 24 × 10 3, affected the clearance rates. Most of the Candidal organisms administered could no longer be isolated after 30 minutes and none were detectable after 4 hours. Under normal circumstances, exposure of healthy non-carriers to C. albicans does not seem to result in oral colonization. Oral thrush probably results from changes in host resistance rather than from exposure to high doses of C. albicans.
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