Abstract
There are many examples of protein cages in nature, from the outer capsid shells of viruses that protect their genetic material, to simple organelle-like structures in bacteria that house enzymes within their interior. This Account serves to introduce the world of protein cages to a chemical audience, and highlight the many similarities to concepts from supramolecular chemistry, revealing how a knowledge base in chemistry can provide the foundation for valuable insights into fundamental questions and biomolecular engineering challenges in the field.
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