Abstract
The suppressor of cytokine signalling-1 (SOCS-1) is a negative regulator of signal transduction mediated by cytoplasmic tyrosine kinases such as the Janus kinases (JAKs). We investigated SOCS-1 expression in bone marrow cells from Philadelphia chromosome negative chronic myeloproliferative disorders (Ph − CMPD) and normal haematopoiesis ( n = 121), and additionally in peripheral blood samples ( n = 18). Except for chronic idiopathic myelofibrosis harbouring wild-type JAK2, other Ph − CMPD expressed significantly higher SOCS-1 levels of up to 14-fold compared to the control group ( p < 0.001) independent of the JAK2 status. The mononuclear cell fraction but not granulocytes in patients with Polycythaemia vera also significantly overexpressed SOCS-1. We conclude that up-regulation of the SOCS-1 gene might reflect a compensatory feedback mechanism with different emphasis among Ph − CMPD subtypes independent of an underlying JAK2 (V617F) mutation.
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