Abstract
UV light, especially UVB, is known as a trigger of allergic reaction, leading to mast cell degranulation and histamine release. In this study, phlorotannin Fucofuroeckol-A (F-A) derived from brown algal Ecklonia stolonifera Okamura was evaluated for its protective capability against UVB-induced allergic reaction in RBL-2H3 mast cells. It was revealed that F-A significantly suppress mast cell degranulation via decreasing histamine release as well as intracellular Ca2+ elevation at the concentration of 50 μM. Moreover, the inhibitory effect of F-A on IL-1β and TNF-α productions was also evidenced. Notably, the protective activity of F-A against mast cell degranulation was found due to scavenging ROS production. Accordingly, F-A from brown algal E. stolonifera was suggested to be promising candidate for its protective capability against UVB-induced allergic reaction.
Highlights
Sunlight is a continuous spectrum of electromagnetic radiation that is divided into three major spectrums of wavelength such as ultraviolet, visible, and infrared [1]
We examined whether F-A alleviates the intracellular Ca2+ level in UVBexposed RBL-2H3 mast cells
Many researchers have shown phenolic compounds fromactivities marine on algae strong possess radio-protective against UVB. These results suggested that the effective antioxidant activities onactivity free radicals and light possess radio-protective activity against light antioxidant activity andsuggested radio-protective ofantioxidant
Summary
Sunlight is a continuous spectrum of electromagnetic radiation that is divided into three major spectrums of wavelength such as ultraviolet, visible, and infrared [1]. The UV range is the most significant spectrum of sunlight with a wavelength from 10 nm to 400 nm, shorter than that of visible light but longer than X-rays. Ultraviolet (UV) radiation is divided into three distinct bands including. UVA (320–400 nm), UVB (290–320 nm), and UVC (200–290 nm) in order of decreasing wavelength and increasing energy [2]. UVC light is absorbed by the atmosphere, while approximately 90–99% of UVA and 1–10% of UVB reaches the earth’s surface [3]. Different wavelengths and energy associated with UV subdivision correspond to distinctly different effects on living tissue.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
