Abstract
1. Diflunisal (DF) is metabolized in rats and humans primarily to its acyl glucuronide, phenolic glucuronide and sulphate conjugates. 2. DF sulphate was synthesized and administered i.v. to conscious bile-exteriorized rats at 10 mg DF equiv./kg. 3. DF sulphate was excreted almost exclusively in urine, and its systemic hydrolysis, monitored by glucuronidation of liberated DF, was quantitatively negligible. 4. Systemic stability of DF sulphate was therefore similar to DF phenolic glucuronide, and contrasted with the systemic instability of DF acyl glucuronide.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
