Abstract
The inhibition of sulphatase A by certain carbonyl reagents and by ascorbate has been shown to require the presence of metal ions in the system. The inhibition is prevented by EDTA which can also reverse any prior inhibition by these reagents. A metal-free preparation of sulphatase A was not inhibited by phenylhydrazine. Copper seems to be the metal primarily involved and it is suggested that these reagents inhibit sulphatase A either by forming an enzymically inactive sulphatase-copper-modifier complex or by reducing Cu 2+ to Cu +, the latter being the true inhibitor of the enzyme. Of these two possibilities the latter seems the more probable but direct proof has not been possible.
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