Abstract
The nonpeptide substance P receptor antagonist CP-96,345 was found to displace binding to Ca 2+ channel binding sites labelled with either [ 3H]desmethoxyverapamil or [ 3H]diltiazem and to enhance [ 3H]nitrendipine binding. Unlike the substance P receptor antagonist activity of CP-96,345, these effects on Ca 2+ channel binding sites were neither stereoselective nor species-dependent. It is concluded that CP-96,345 may act as an antagonist of L-type Ca 2+ channels in addition to being a potent NK 1 receptor (substance P) antagonist.
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