Abstract
10mg/kg group showeddecreasedmesor and increased amplitude. (p=0.000). Conclusions: Therewas a rhythmic increase in locomotor activity during the dark period and a decrease in activity in the light period. 0.6mg/kg failed to elicit change in locomotor activity pattern in ED2 and 7 but was able to alter the activity pattern at ED11. The 2.5 and 10.0mg/kgMPD doses elicit an increased average locomotor activity in all days and modulate the circadian locomotor activitypattern inED7,8, and11, suggesting that all doseshave long term effect on animal behavior. These long-term changes suggest that permanent changes at themolecular level occurred, expressed by tolerance, sensitization and even in the circadian gene clock that result in alteration in the circadian rhythm activity pattern. Financial support: NIH RO1 DA027222.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
