Abstract
Evidence supporting the existence of three aldehyde dehydrogenases, betaine aldehyde dehydrogenase and two aldehyde dehydrogenases ALDH-I and ALDH-II, in rat liver has been confirmed. Subcellular fractionation indicates that betaine aldehyde dehydrogenase is predominantly in the cytosol with about 5% in the mitochondria. Of the aldehyde dehydrogenase activity (ALDH-I plus ALDH-II) 80% is found in the mitochondria and 20% in the microsomal fraction. Of the two enzymes ALDH-I is exclusively mitochondrial and ALDH-II is distributed between mitochondria and microsomes. Submitochondrial fractionation indicates that betaine aldehyde dehydrogenase and ALDH-I are located in the matrix, and that ALDH-II is chiefly located in the outer membrane.
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