Abstract
A cardioexcitatory peptide is associated with a sedimentable fraction of homogenized pericardial organs from Cancer borealis; this fraction contains numerous electron-dense granules of diameter ca 1500 Å. The association of the peptide with the fraction depends on the osmolarity of the granule suspension. The cardioexcitatory peptide exists in a “free” form, which can be released from a granule suspension by dilution with distilled water, and in “bound” form, which can be released by further treatment of the suspension with acetic acid. 5-hydroxytryptamine is probably associated with a sedimentable particle different from that containing the peptide material.
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