The study on the association between tissue plasminogen activator-plasminogen activator inhibitor-1 complex and risk of coronary disease

Abstract

Objective The aim of this study was to discuss the effect and clinical value of plasma Tissue Plasminogen Activator-Plasminogen Activator Inhibitor-1 Complex (t-PAIC) in the coronary heart disease (CAD). Methods This is a retrospective study. From January 2017 to March 2018, 203 patients with CAD were recruited from Renmin Hospital of Wuhan University. 130 cases were selected for control group at the same period. Plasma concentrations of t-PAIC, blood RBC, Hb, WBC and other routine biochemical markers were quantified. Results The plasma t-PAIC level in CAD group 12.75(9.0-17.93) ng/ml was significantly higher than that in healthy control group 7.70(6.10-9.41) ng/ml (Z=9.208, P<0.001). Logistic regression analysis showed that the TG, LPa, t-PAIC were independent risk factors for CAD[OR(95%CI)], [1.762(1.076-2.884); 1.002(1.000-1.003); 1.338 (1.171-1.529)]. The t-PAIC level was positively correlated with the severity of CAD. Compared with control group, the level of t-PAIC was higher in mild group(11.64±0.59)ng/ml and severe group(15.84±0.72)ng/ml, and the plasma t-PAIC level was positively correlated with Gensini score(r=0.471, P<0.001). Multiple linear regression analysis showed that there was a positive correlation among the plasma t-PAIC and LDL-C, Glu, WBC (β coefficient=0.673, 0.305, 0.263, P=0.037, 0.002, 0.006). In addition, there was abnormal increase of plasma t-PAIC in CAD patients with poor prognosis (H=82.210, P<0.001). Conclusion Plasma t-PAIC is an independent risk factor of CAD. The significantly increase of plasma t-PAIC might be an important predictor of incidence of CAD and unfavourable prognosis. (Chin J Lab Med, 2018, 41: 420-424) Key words: Coronary disease; Tissue plasminogen activator; Plasminogen activator inhibitor 1; Risk factors