The Study on the Antibacterial Effects of Several Traditional Chinese Medicines

Abstract

Objective: The effective components of <i>Fructus Aurantii</i>, <i>Pulsatilla chinensis</i>, <i>Schisandra chinensis</i>, <i>Sanguisorba officinalis</i>, <i>Scutellaria baicalensis</i>, <i>Terminalia chebula</i>, <i>Rheum officinale</i>, <i>Punica granatum</i>, <i>Fructus Mume</i>, <i>Cortex Phellodendri</i> and <i>Coptis chinensis</i> were extracted, and the minimum inhibitory concentrations of components from these Traditional Chinese Medicines were analyzed in vitro against <i>Staphylococcus chromogenes</i>, <i>S. xylosus</i>, <i>S. pseudintermedius</i>, <i>Yokenella regensburgei</i>, <i>Aeromonas hydrophila</i> and <i>Klebsiella pneumoniae</i>, so as to lay a theoretical foundation for the application and development of Traditional Chinese Medicine in clinical treatment. Methods: The effective components of Traditional Chinese Medicines were extracted by alcohol extraction, and the minimal inhibitory concentration of single Traditional Chinese Medicine was determined by tube dilution method. Results: <i>S. chinensis</i>, <i>P. granatum</i>, <i>F. Mume</i> and <i>T. chebula</i> showed the most significant bacteriostatic effects on <i>S. xylosus</i> (MICs were all 62.50 mg/mL); <i>S. chinensis</i> presented the most significant antibacterial effect on <i>S. chromogenes</i> (MIC was 31.25 mg/mL); <i>S. chinensis</i>, <i>P. granatum</i> and <i>T. chebula</i> had the most significant bacteriostatic effects on <i>S. pseudointermedia</i> (MICs were all 31.25 mg/mL); <i>S. chinensis</i>, <i>S. officinalis</i>, <i>T. chebula</i>, <i>R. officinale</i>, <i>F. Mume </i>and <i>C. chinensis</i> had the most significant bacteriostatic effects on <i>Y. regensburgei</i> (MICs were all 15.60 mg/mL); The inhibitory effect of <i>S. officinalis</i> on <i>A. hydrophila</i> was the most significant (MIC was 1.95 mg/mL); <i>F. Mume</i> had the most significant antibacterial effect on <i>K. pneumoniae</i> (MIC was 0.98 mg/mL). Conclusion: <i>S. chinensis</i>, <i>F. mume</i> and <i>T. chebula</i> et al. have good antibacterial effects, thus providing basis for the clinical application of these Traditional Chinese Medicines.