THE STUDY ON RELAPSE OF IDI?P???I? NEPHROTIC SYNDROME IN CHILDREN

Abstract

One of the main subjects of idiopathic nephrotic syndrome in children today is prediction and prevention of relapse. In this study, we predicted relapses of idiopathic nephrotic syndrome immunologically. Detection of inhibitory factors for Con-A induced lymphoblastogenesis in the nephrotic plasma was carried out, and the factors were expressed as inhibition index. In remission, the inhibitory factors seemed to disappear, while in relapse and 2 to 4 weeks prior to relapse as well as at the onset, the indices were abnormally high. Molecular weight identification of the inhibitory factors was carried out on the patients' sera at the onset and in relapse by Sephadex G-200 gel chromatography. The results revealed three peaks with strong inhibitory activity. One is probably glycoprotein at more than 6X105 molecular weight, and the others are multifactors with 3 - 7×104 in molecular weight and peptide at 6×103 molecular weight. We believe the inhibitory factors exist in nephrotic sera at the onset as well as in relapse. Prediction of the relapse is possible 2 to 4 weeks prior to actual relapse. Preventive therapies can be applied successfully.