The Study Of Urinary Tract Infections And Antibiogram Of Uropathogens In And Around Ahmadnagar, Maharashtra.

Abstract

Background and Objectives: Urinary tract infections (UTI) are one of the most commonly occurring infections in hospitals. But micro organisms causing UTI vary in their susceptibility from place to place and from time to time. This study was designed to determine the prevalence and antibiotic susceptibility patterns of common urinary bacterial isolates in and around Ahmadnagar, Maharashtra.Methods: Seven hundred and ninety five urine specimens from clinically suspected UTI patients were examined by Semi quantitative culture method and their antimicrobial sensitivity patterns were determined by Kirby-Bauer disc diffusion technique.Results: In total one hundred ninety five pathogenic isolates (isolation rate 24.52%) were obtained with the maximum isolation rate in between 21-40 years age group of patients. The rate of culture positivity in females was 63.6% (124/195), whereas in males it was 36.4% (71/195). Among the isolates E. coli was the predominant isolate (72.3%) followed by Klebsiella spp (13.33%), Pseudomonas aeruginosa (5.64%), Proteus spp. (3 %) and Citrobacter spp, Candida albicans, S faecalis, Staph aureus approximately 1-2% each. Sensitivity tested against various antimicrobials showed maximum sensitivity against Imipenem (94.3%), Cephotaxime, Cefepime, Amikacin in order of sensitivity. Substantial resistance was shown to Gatifloxacin by almost all important gram negative isolates, which is one of the newly introduced fluoroquinolones and resistance to third generation cephalosporin, Ceftazidime was also noticed.Interpretation: Females predominated over males in both incidence7 as well as in rate of culture positivity. The aetiology of UTI was similar to previously established, known pathogens with E. coli accounting for more than 70 percent infections. The antibiogram of different isolates observed emphasizes the judicial usage of antibiotics.Conclusion: We conclude that maintaining a record of culture results and the antibiogram may help clinicians to determine the empirical and / or specific treatment based on the antibiogram of the isolate for better therapeutic outcome.