Abstract
The presence of Demodex folliculorum mites exacerbates the number of dermatological conditions, such as rosacea and perioral dermatitis, and complicates their treatment. Development and introduction of medicines with the complex action in practical medicine exhibiting anti-parasitic properties against Demodex folliculorum and possessing the antibacterial, anti-inflammatory, capillary-restorative, anti-edemic, antioxidant and anti-allergic effect are of great current interest. One of the stages of introduction of new medicines is to study toxicity, which allows to assess their safety. Acute toxicity, the skin-irritant effect of the cream containing metronidazole, salicylic acid, troxerutin and essential oil of lemon balm, as well as its anti-alterative activity have been experimentally investigated on the model of non-allergic contact subchronic dermatitis caused by turpentine. The results obtained show no toxicity and skin-irritant effect of the cream with a single topical application to rats in the doses of 500 and 15000 mg/kg; it allows to refer it to Class VI of practically non-toxic substances (LD > 15000 mg/kg) in accordance with the generally accepted classification of K.K.Sidorov. As a result of the study of the anti-alternative activity on the model of non-allergic contact subchronic dermatitis caused by turpentine it has been found that the cream under research reveals the anti-inflammatory action.
Highlights
The composition of a cream that contains metronidazole, salicylic acid and troxerutin under conditional name “Metroxal” has been developed
Acute toxicity was studied by G.V.Pastushenko method on nonlinear outbread mature white rats of both sexes weighing 180-230 g with a single cutaneous application using two dose levels
The study of anti-alternative properties of “Metroxal” cream was performed on the model of nonallergic contact subchronic dermatitis caused by turpentine [2]
Summary
The composition of a cream that contains metronidazole, salicylic acid and troxerutin under conditional name “Metroxal” has been developed. Salicylic acid exhibits antibacterial and anti-inflammatory, keratolytic or keratoplastic (5%) properties, troxerutin provides venotonic, capillary-restorative, angioprotective, anti-edemic, antioxidant and antiinflammatory effects [6]. L.M.Maloshtan – Doctor of Biology, professor, head of the Physiology Department, head of the Morphofunctional Research laboratory of the National University of Pharmacy (Kharkiv) tential use in medical practice. Taking it into consideration the purpose of our work was to study the acute toxicity and to evaluate the possible effect of the local irritating action of the cream developed
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
