Abstract
In order to increase the post-vaccination immune response during vaccination of calves against salmonellosis, a test was carried out with an inactivated emulsified vaccine against the background of the use of the probiotic Profort. The studies were carried out on the basis of a large livestock farm in the Voronezh region, unfavorable for salmonellosis of calves. Epizootological, clinical, immunological, hematological, molecular genetic research methods were used in the work. Studies have shown that vaccination of calves against salmonellosis against the background of the use of the probiotic preparation Profort with an inactivated emulsified vaccine contributed to the development of intense cellular immunity – an increase in the total number of lymphocytes and T-cells by 7.0%, B-cells – by 2.8%%, phagocytic activity of neutrophils - by 5.9%, phagocytic number – by 7.2%, phagocytic index – by 7.0%, as well as humoral immunity factors – BaS by 3.0%, LaS – by 3.0%%, CaS – by 1.7%, O- and H-agglutinins to salmonella antigen – 1.5 and 2 times, respectively. The use of Profort increases the protective properties of the vaccine against salmonellosis, helps to reduce the incidence by 13.3%, and increase the safety of young animals by 26.6%. Therefore, to optimize the use of Profort probiotic, it is necessary to take into account its immunomodulatory effect.
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