Abstract
The search for the most effective hepatoprotective agents is an urgent problem of modern medicine. As a rule, crude plant is promising object for the study of medicinal properties. Based on the literature data, we are interested in the horticultural crops Prunus domestica , the family Rosaceae , which is quite cultivated and attracts attention to its pharmacoeconomic component. The purpose of the study. In previous experimental studies, the Prunus domestica extract, containing fibers, was found to have laxative, hepatoprojector and probiotic effects. The foregoing provided an opportunity to study the Prunus domestica extract, containing fibers for activity in the comorbidization of several relevant pathologies and to experimentally substantiate the prospect of its application as a means of choice for constipation in patients with pathologies of the digestive system. Materials and methods. The object of research was a dry extract from Prunus domestica fruits, containing fibers. The experiment was carried out in stages. At the first stage, the animals caused experimental subacute alcoholic liver damage. In the second stage of the experiment, the animals were modeled with functional constipation. During the course of subacute hepatosis and during the second phase of the experiment, the test extract was injected into the animal at a dose of 200 mg/kg and the reference drug was hepatoprotector Silybor at a dose of 25 mg/kg. In the second phase of the study, the laxative agent Senadexin at a dose of 14 mg/kg was added to the therapy. All substances were injected into the body of the experimental animals orally. To evaluate the motor activity of the intestine, Sagar et al, modified by Choi et al., was used. Motor activity of the small intestine was determined according to the corresponding calculation formula. The functional state of the liver was evaluated according to the biochemical parameters in the blood serum: the total protein, urea and ALT activity. Results. An analysis of experimental data showed that the test extract exhibits a moderate laxative effect. In animals of the intact group, the relevant signs (pronounced laxative effect) indicate the development of diarrhea, which is not an adequate solution to the development of constipation. With the use of the extract from Prunus domestica fruits during the whole period of the experiment, normalization of all indicators that characterize the intestinal motility was observed. Analysis of experimental data showed that the investigated phytoobject has a soft laxative effect, mainly through the improvement of intestinal motility. In the study of the functional state of the liver on the introduction of the investigated extract, positive changes in the content of markers of liver damage (decrease in urea concentration and decrease in the activity of ALT in animal serum) were detected in comparison with the control group of animals. Conclusions. The obtained experimental data on the study of the correlation mechanisms of hepatoprotective and laxative activity of the extract from Prunus domestica fruits containing fibers indicate that there is a soft laxative effect that is realized with the help of intensifying intestinal motility, as well as the presence of pronounced hepatoprotective action. The indicated effects of the investigated extract were revealed when used in the treatment of constipation on experimental subacute liver damage, while not losing out to the studied effects in the complex application of hepatoprotective and laxative comparisons. The key conclusion is that the test extract, as opposed to the reference drug, does not cause signs of diarrhea in its laxative effect, which can be a distinctive, positive feature in further clinical studies. This herbal object can be promising and rational in application with single-stage complex therapy, such as hepatoprotective and laxative agent in the treatment of comorbid conditions in gastroenterology associated with diseases of the liver and congestive intestinal phenomena.
Highlights
The study object was the dry extract from Prunus domestica fruits containing fibers
The experimental data obtained on the study of the correlation mechanisms of the hepatoprotective and laxative activity of the extract from Prunus domestica fruits containing fibers indicate the presence of a soft laxative effect that occurs by intensifying the intestinal motility, as well as the pronounced hepatoprotective action. These effects of the extract studied were revealed when using it in the treatment of constipation against the background of the experimental subacute liver damage, not being inferior the effects studied in the complex application of the hepatoprotective and laxative reference drugs
The key conclusion is that the extract studied, in contrast to the reference drug Senodexin, does not cause signs of diarrhea in its laxative effect, which can be a distinctive, positive feature in further clinical studies
Summary
The study object was the dry extract from Prunus domestica fruits containing fibers. The experiment was performed in stages. The experimental subacute alcoholic liver damage was caused in animals. At the second stage of the experiment, functional constipation was modeled in animals. In the course of subacute hepatosis and during the second phase of the experiment animals were introduced the test extract in the dose of 200 mg/kg and the reference drug – a hepatoprotector Silybor in the dose of 25 mg/kg. At the second stage of the study, a laxative Senadexin in the dose of 14 mg/kg was added to the therapy. To assess the motor activity of the intestine, the method of Sagar et al, modified by Choi et al, was used. The functional state of the liver was assessed by the biochemical parameters in the blood serum: the total protein, urea and ALT activity
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