THE STUDy OF THE NEUROPSyCHOPHARMACOLOGICAL EFFECTS OF THE NEW DERIVATIVE OF GLUTAMIC ACID, THE RGPU-197 COMPOUND

Abstract

Proceeding from the proposition about the high productivity of the search of neuropsychotropic substances among the derivatives of natural neuromediators, a study of neuropsychopharmacological effects of the derivative of the glutamic acid, RGPU-197 compound was carried out. The study was carried out on the he-rats of the Wistar line using the following tests: “open field”, elevated plus maze, conditioned passive-avoidance response, the test of extrapolational deliverance, the test of hanging mice by tails; and also the methods of statistic analysis: rank univariate analysis of Cruscal-Wallace, the Dunn multiple comparison test /the multiple comparison test of Dunn, the x2 criterion. The RGPU-197 compound significantly (p<0,05, p<0,01) decreases the duration of immobilization of the animals and expands the latent period of its approach in the test of hanging mice by tails — it possesses antidepressant activity; increases the quantity of the visits of the centre of the open field, the quantity of attendings of the open hoses of elevated plus maze and the time of stay in them — it shows anxiolytic action; increases the quantity of crossed squares in the open field and the quantity of crossings between the hoses of elevated plus maze — it possesses activating effect; during the displays of the avoidance reflex it expands the latent period of the first period of entering the dark compartment and the quantity of enterings of it in conditioned passive-avoidance response, reduces the latent period of diving under in the test of extrapolational deliverance — it shows nootropic action. According to the intensity of antidepressant action RGPU-197 doesn’t yield to melipramin, anxiolytic and activating effects significantly (p<0.05) excels phenibutum and doesn’t yield to it by nootropic activity. Thus, the new derivative of glutamate, the RGPU-197 compound, possesses the marked antidepressant, anxiolytic and activating effects, as well as nootropic activity.