Abstract
Genetic diseases can be caused by pure genetic factors or a combination of genetic and environmental factors. Mutations can occur in the autosomal chromosomes (chromosome 1−22), the sex chromosomes (X or Y), or the mitochondrial genome. Genetic diseases are transmitted from parents to offspring and can be categorized into two groups; monogenic and complex diseases. Monogenic diseases are caused by mutations in a single gene and complex diseases are caused by several genes in interaction with each other as well as with environmental factors. Systemic lupus erythematosus, SLE, is a systemic autoimmune disorder. The disease is characterized by chronic inflammation in different organ systems and autoantibodies against intracellular components such as dsDNA. The disease primarily affects women with a female to male ratio of 9:1. SLE is considered to be a complex disease, caused by interaction between genetic and environmental factors. In complex diseases multiple genetic factors with unknown mode of inheritance contribute to the disease. The susceptibility genes are thought to work together to cause the disease where neither gene is necessary nor sufficient. This review deals with the basis of the studies on genetics of complex diseases and what is known to date on the genetics of systemic lupus erythematosus.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
