The Study of the Expression of CGB1 and CGB2 in Human Cancer Tissues.

Piotr Białas,Anna Szczerba,Aleksandra Śliwa,Anna Jankowska

doi:10.3390/genes11091082

Piotr Białas, Anna Szczerba + Show 2 more

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https://doi.org/10.3390/genes11091082

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Journal: Genes	Publication Date: Sep 17, 2020
Citations: 6	License type: CC BY 4.0

Affiliation: Poznan University of Medical Sciences

Abstract

Human chorionic gonadotropin (hCG) is a well-known hormone produced by the trophoblast during pregnancy as well as by both trophoblastic and non-trophoblastic tumors. hCG is built from two subunits: α (hCGα) and β (hCGβ). The hormone-specific β subunit is encoded by six allelic genes: CGB3, CGB5, CGB6, CGB7, CGB8, and CGB9, mapped to the 19q13.32 locus. This gene cluster also encompasses the CGB1 and CGB2 genes, which were originally considered to be pseudogenes, but as documented by several studies are transcriptionally active. Even though the protein products of these genes have not yet been identified, based on The Cancer Genome Atlas (TCGA) database analysis we showed that the mutual presence of CGB1 and CGB2 transcripts is a characteristic feature of cancers of different origin, including bladder urothelial carcinoma, cervical squamous cell carcinoma, esophageal carcinoma, head and neck squamous cell carcinoma, ovarian serous cystadenocarcinoma, lung squamous cell carcinoma, pancreatic adenocarcinoma, rectum adenocacinoma, testis germ cell tumors, thymoma, uterine corpus endometrial carcinoma and uterine carcinosarcoma.

Highlights

Human chorionic gonadotropin is a heterodimeric hormone, which comprises two non-covalently linked subunits: alpha (α) and beta (β)
All values of gene expression were presented as transcripts per million (TPM)—a normalization method for RNA-seq which represents the relative abundance of a gene or transcript in a sample
The screening of TCGAcancers transcriptome data related to CGB1 and CGB2 gene expression in different

Summary

Introduction

Human chorionic gonadotropin (hCG) is a heterodimeric hormone, which comprises two non-covalently linked subunits: alpha (α) and beta (β). Most gonadotropins are synthesized by the anterior pituitary gland, hCG synthesis takes place in the placenta as a result of syncytiotrophoblast cells activity [4]. Human chorionic gonadotropin participates in and regulates many physiological processes related to the normal course of pregnancy, which includes: maintenance of progesterone production by the corpus luteum, chorionic villi development, embryo implantation, or angiogenesis [5]. HCG determines the mother’s immunotolerance to the antigens presented by the developing fetus [6,7]. Especially its β subunit (hCGβ) is secreted in gestational trophoblastic disease, and by a large group of non-trophoblastic tumors. Especially its β subunit (hCGβ) is secreted in gestational trophoblastic disease, and by a large group of non-trophoblastic tumors. hCGβ expression has been observed in tumors of different origin such as: breast, cervix, prostate, lung, colon, kidney, bladder, pancreas, anus, vulva, ovary, brain, endometrium and mouth [8,9]

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