The study of the emulsification efficiency of Aerosil and HPMCAS type and their ratio to stabilize emulsions of zedoary turmeric oil

Abstract

The solid particles or polymers were often solely used to stabilizing emulsions, as an interesting alternative to classical used emulsifiers. However, a united use of them and the relation between them at stabilizing emulsions were little reported. Our previous study showed that the preparation of microspheres containing zedoary turmeric oil (ZTO, as an oily drug), Aerosil200 particles and hydroxypropyl methylcellulose acetate succinate (HPMCAS). ZTO emulsions were produced when the microspheres were immersed into aqueous media and disaggregated under gentle agitation, and were stabilized by Aerosil200 particles and HPMCAS. Nevertheless, more work needs to be carried out to explain the factor affecting emulsification efficiency of microspheres, which will facilitate the design of the microsphere formulation. Thus, in this study, we dealt with a system consisting of Aerosil, HPMCAS, ZTO and water. To predict the best ratio of Aerosil/polymer and thus obtain the best satisfying ZTO emulsions, the bonding studies were carried out with Aerosil and HPMCAS. A series of emulsions was prepared and the stability and droplet size of resultant emulsions were investigated. The results indicated two kinds of HPMCAS (HPMCAS-LG and -HG) showed the different affinity for Aerosil200, which resulted in the unlike capability to stabilize emulsions when at the same Aerosil/polymer ratio. The stability and droplet size of emulsions increased on increasing the ratio Aerosil to polymer, and the best ratio was predictable from the Langumuir-fit of the adsorption isotherms. Appropriate hydrophilicity and hydrophobicity with Aerosil particles were very important to stabilizing the ZTO emulsions.