Abstract
In this study we evaluated dichloromethane (DCM) extract obtained from C. fenestratum, for its ability to protect the gastric mucosa against injuries caused by necrotizing agents (0.3M HCl/60% EtOH), hypothermic restraint stress, and non‐steroidal anti‐inflammatory drugs (NSAID, indomethacin). Total phenoic content and free radical scavenging effects of the bioactive compounds were also determined. In the HCl/EtOH‐induced gastric‐ ulcer model, DCM extract demonstrated significant inhibition of ulcerative lesion index by 98% in relation to the positive control value 72.93 % (p< 0.05), 81% as compared to the positive control group 78.82% (p<0.05) in the NSAID/indomethacin –induced lesion model and 81.97% compared to positive control 73.77% (p< 0.05) in hypothermic‐restraint stress induced gastric acid ulcer model. The radical scavenging activity of the extract was 21.71% which was closely related to the total phenolic content of 256.67mg GAE/g dry weight. HPLC‐UV‐MS profiling of the bioactive compound in the DCM extract confirmed the presence of polyphenolic compounds. From this result we conclude that this extract possess a significant protective effect against gastric mucosa injuries caused by 0.3M HCl/60% EtOH, hypothermic restraint stress, and NSAID/indomethacin in the experimental rats. These effects may be due to the presence of polyphenolic compounds that provided radical scavenging activity.
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