Abstract
Research of the action of the thick extract from the leaves of Corylus avellana on the vascular-tissue permeability of the rats skin has been conducted. Effect of the thick extract from the leaves of Corylus avellana on vascular tissue permeability in rats has been assessed by the time of papules coloring (animal skin at the injection side of flohohen substances) in seconds. We used formalin, histamine, protein, which have different mechanisms of action on capillary permeability. In the group, which has been administrated with the studied extract at its conditional therapeutic dose of 60 mg/kg we have observed the decrease of vascular permeability induced by flohogene substances. It was determined that the most pronounced vessel strengthening effect during the experiment with histamine, where papules coloring has been 1.9 times slower compared with the control group. In comparison with eskuvit the data rates has been approaching to 1. Taking into consideration the mechanism of the action of the applied flohogenes we can suggest that an extract from the leaves of Corylus avellana detects an expressed validity of capillaries permeability and mikrocirculations. Extract showed a moderate effect against the background of formalin and protein inflammation, but this index has exceeded the index of the eskuvit group by 170 seconds against the background of formalin inflammation. The obtained results indicate the presence of capillary resistance activity that is cause for further research of the efficiency of the extract in experimental pathology.
Highlights
Materials and MethodsThe study object was the thick extract from the leaves of Corylus avellana, obtained at the Department of Chemistry of Natural Compounds of the National Pharmaceutical University under the supervision of professor Khvorost O.P. All studies were performed on 24 white outbred rats weighing 180-200 g with 6 rats in each group
National University of Pharmacy Institute for Continuing Education of Pharmacy Professionals at the National University of Pharmacy*
In the group with formalin they were 1.6 times slower compared to the control pathology group, and this index exceeded the index of the eskuvit group by 170 s
Summary
The study object was the thick extract from the leaves of Corylus avellana, obtained at the Department of Chemistry of Natural Compounds of the National Pharmaceutical University under the supervision of professor Khvorost O.P. All studies were performed on 24 white outbred rats weighing 180-200 g with 6 rats in each group. The animals received standard food according to the current regulations [5]. They were treated according to the rules of the “European Convention for the protection of vertebrate animals used for experimental and scientific purposes” (Strasbourg, 1986). The effect of the thick extract from the leaves of Corylus avellana on the vascular tissue permeability by Golikov P.P. method, 1964 (n=24)
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