Abstract
目的 探讨肝硬化患者大脑基底节和白质的弛豫时间与肝硬化严重程度及血氨值的关系,评价MRI弛豫时间测量对肝硬化累及脑组织的诊断价值.方法应用MR SE脉冲序列对22例肝硬化患者[其中男20例,女2例,平均年龄(46.4±8.1)岁] 和18位成人健康志愿者[男16例,女2例,平均年龄(42.4±8.4)岁]行MR检查,应用经典SE脉冲序列2点法测量和计算苍白球、壳核、尾状核头、丘脑和大脑白质的T1和T2值.在MR扫描后1周内,对其中8例患者行血氨水平测定.结果 15例肝硬化患者T1WI可见基底节区信号增高,7例无明显异常改变.7例T2WI基底节区信号明显减低,15例无明显异常改变.肝硬化患者苍白球、壳核、尾状核头、丘脑与皮层下白质的T1值均与正常对照组差异有非常显著性意义(P 0.05).结论 MRI大脑基底节T1值测量可用于评价肝硬化及其所致脑组织变性的严重程度。
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