Abstract
Aim.The research was designed to study the renoprotective properties of erythropoietin derivatives on the kidney ischemiareperfusion experimental model.Materials and methods.The renoprotective properties of asialo erythropoietin (0.4 μg/kg and 2.4 μg/kg 30 minutes before the induction of ischemia) and carbamylated darbepoetin (50 μg/kg 24 hours before the ischemic stimulus) were studied in comparison with erythropoietin and darbepoetin in a series of experiments on male Wistar rats on a 40-minute bilateral model of renal ischemia-reperfusion. The renoprotective properties were evaluated by the results of biochemical markers of acute kidney injury, the dynamics of glomerular filtration rate and fractional sodium excretion, as well as the severity of microcirculatory disorders.Results.It was found that the prophylactic use of asialo erythropoietin (dose-dependent) and carbamylated darbepoetin leads to a decrease in the serum concentration of markers of acute renal damage, an increase in the glomerular filtration rate, a decrease in fractional sodium excretion, and a decrease in microcirculatory disorders.Conclusion.Asialo erythropoietin and carbamylated darbepoetin have the pronounced renoprotective properties and are the promising agents for the prevention and treatment of acute kidney injury.
Highlights
The research was designed to study the renoprotective properties of erythropoietin derivatives on the kidney ischemiareperfusion experimental model
The renoprotective properties were evaluated by the results of biochemical markers of acute kidney injury, the dynamics of glomerular filtration rate and fractional sodium excretion, as well as the severity of microcirculatory disorders
It was found that the prophylactic use of asialo erythropoietin and carbamylated darbepoetin leads to a decrease in the serum concentration of markers of acute renal damage, an increase in the glomerular filtration rate, a decrease in fractional sodium excretion, and a decrease in microcirculatory disorders
Summary
Изучить ренопротективные свойства производных эритропоэтина на экспериментальной модели ишемии-реперфузии почек. В серии экспериментов на крысах-самцах линии Wistar изучали ренопротективные свойства асиалированного эритропоэтина (0,4 мкг/кг и 2,4 мкг/кг за 30 минут до индукции ишемии) и карбамилированного дарбэпоэтина (50 мкг/кг за 24 часа до ишемического стимула) в сравнении с эритропоэтином и дарбэпоэтином на 40-минутной билатеральной модели ишемии-реперфузии почек. Ренопротективные свойства оценивали по результатам биохимических маркеров острого почечного повреждения, динамики скорости клубочковой фильтрации и фракционной экскреции натрия, а также выраженности микроциркуляторных нарушений. Установлено, что профилактическое применение асиалированного эритропоэтина (дозозависимо) и карбамилированного дарбэпоэтина приводит к снижению сывороточной концентрации маркеров острого почечного повреждения, росту скорости клубочковой фильтрации, снижению фракционной экскреции натрия и уменьшению микроциркуляторных нарушений. Для цитирования: Елагин В.В., Костина Д.А., Братчиков О.И., Покровский М.И., Покровская Т.Г. For citation: Elagin V.V., Kostina D.A., Bratchikov O.I., Pokrovsky M.V., Pokrovskaya T.G. The study of renoprotective properties of erytropoetin derivatives on the kidney ischemia-reperfusion model.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
