The study of relationship between the change of microbial population pre and post-renal transplantation and clinical infection

Abstract

Objective To study the relationship between the change of microbial population pre-and txast-renal transplantation and clinical infection.Methods 169 patients undergoing renal transplantation were randomly selected to determine the microbial population pre- and post- transplantation and to observe the incision infection rate and bacteria and fungas local or systemic infection rate.84 cases of them received Cefuroxime and remaining 85 cases received Peniciline or Cephradine as control group.Results The microbial population before transplantation included(in a order of high frequency to low frequency):streptococcus viridans,Branhamella catarrhalis,escherichia coli,proteus vulgaris,mirabilis,Klelsiella pneumoniae,haemophilus influenzae,citrobacter secies,pyocyaneus aemginosa,staphylococcus aureus, micrococcus lanceolatus,candida albicans.The microbial population of lung infection after transplantation contained(in a order of high frequency to low frequency) Klelsiella pneumoniae,haemophilus influenzae,escherichia coli,citrobacter secies,bacillus cloacae,staphylococcus aureus,micrococcus lanceolatus,streptococcus pneumoniae,streptococcus faecalis,enterococcus faecalis.Fungas population was consisted of candida,penicillium marneffei,cryptococcus neoformans,aspergillus fumigatus fresenius.Incision infection rate was 3%.Conclusions There was some positive relationship between the change of microbial population pre-and post-renal tranplantation and clinical infection.The use of antibiotic around renal transplantation might decrease infection rate. Key words: Kidney transplantation; Infection; Microbial population