The study of relationship between smoking and symptomatic osteoarthritis of weight-bearing or axial joints

Abstract

Objective To clarify the effect of smoking and related factors in symptomatic osteoarthritis disease, and explore the method to analyze the osteoarthritis (OA) risks. Methods Based on the investigation of 7 126 rural residents in Shanxi province, according to whether patients had related factors of symptomatic osteoarthritis in longitudinal axis arthrosis, the single factor and multiple factors logistic regression analysis were adopted to reveal the interaction between risk factors, and the interaction on multiplicative scale and the interaction on additive scale were both analyzed; interaction on multiplicative scale was estimated byOR, the interaction on additive scale was estimated by the relative excess risk due to interact (RERI), the attributableproportion due to interaction (AP), and the synergy index (S). Results The survey included 7 126 residents,in which 1 480 cases osteoarthritis patients in vertical axis joint with the prevalence of 20.8%. By multiple logistic regression analysis, the whole samples by enter level 0.05 level was stepwisely filtered. The results showed that gender, body mass index (BMI), smoking, age, heatable adobe, picky eater, working under coal mine were main influencing factors for the symptomatic arthritis. Balance other influence factors, passive smoking had an effect on arthritis. After adjusting for weight, smoking was not included in the final model. In the stratified interaction analysis, there was interaction on multiplicative scale between smoking and weight (OR= 0.32,P=0.03), and the interaction on additive scale between passive smoking and gender or weight exists [RERI (95%CI) 0.41(0.01, 0.81)>0, AP(95%CI) 0.25(0.01, 0.51)>0, S=3.04>1]. Conclusion The influence of smoking on osteoarthritis is so weak that it could not be a risk factor and its influence on osteoarthritis is initiated via body. Key words: Osteoarthritis; Smoking; Interaction