The study of prevention and control of corneal ulcer nearly perforating with duplex covering

Abstract

Objective To study the possibility of treating corneal ulcer nearly perforating with amniotic membrane transplantation combined with conjunctive valve repairing and evaluate its efficacy.Methods Thirty-eight eyes of 33 patients with corneal ulcer nearly perforating were investigated in the study.The ulcer surfaces were cleaned through surgery after infection controlled,on the bottom of which two or three layers of fresh,antibody-negative and aseptic processing amniotic membranes were placed,then a piece of amniotic membrane with 2mm larger than the ulcer surface was put on it and fixed with suture.Results The operation of 38 eyes was successful.After the operation,2 eyes' conjunctive valves were exposed to the transplanting cornea,but the amniotic membranes were not off.Self-dissolution occurred in 2 eyes' amniotic membranes without perforation.Conclusions Providing basic membranes for ulcer defects,amniotic membrane transplantation may improve the repairing of corneal ulcer in early course and reduce the formation of scar.Duplex coveting can help local blood circulation and infiltrate medicine into ulcer in order to control inflammation,prevent corneal perforation,save eyeball and improve vision. Key words: Corneal ulcer; Nearly perforating; Duplex; Covering