The study of ovulatory pattern following use of clomiphene citrate and anastrozole in infertile women with ovulatory dysfunction: A comparative study

Abstract

Objective: To determine an efficacy of Anastrozole compared with clomiphene citrate to induce follicular growth and ovulation in infertile women with ovulatory dysfunction. Study Design: Comparative prospective study setting: The study was carried out in the department of Obstetrics and Gynaecology at AVBRH, Sawangi, Wardha. Patient(s): The study comprised a total of 100 infertile women (cycles) with ovulatory dysfunction. Intervention(s): Patient received anastrozole (1 mg /d;50 patient , 87 cycles) and CC (50 mg /d ;50 patient, 74 cycles) for 5 days , starting on day3 of mense. Result(s): In 1st treatment cycle the ovulation rates for anastrozole at 1 mg was 32% (n=50) ,compared with 54% (n=50) for Clomiphene citrate at 50 mg/d. in up to 3 cycles of treatment, cumulative ovulation rate was 59.4% with CC and 43.6% with anastrozole. Conclusion(s): CC 50 mg exerts a stronger stimulatory effect on follicular growth compared with 1 mg of anastrozole . Anastrozole was associated with significantly fewer mature and growing follicle and thicker endometrium.