Abstract
In this study investigation of influence of hybrid nanosilica-polyethylene glycols materials (molecular weight 1500, 6000 and 15000), prepared by sol-gel synthesis, on lipid peroxidation and antioxidant activity of human serum in vitro was performed. Methods included chemiluminescence analysis and quantitative malonic dialdehyde estimation. It was revealed that nanosilica-PEG materials with different molecular weight had certain biological activity. Powders of SiO2-PEG 1500 and SiO2-PEG 6000 manifest prooxidant effects, whereas mesoporous (calcine) powders produced antioxidant effects in blood serum in vitro.
Highlights
It was revealed that nanosilica-PEG materials with different molecular weight had certain biological activity
The study of free-radical processes of lipid oxidation and antioxidant system is an important problem of modern biomedicine
Qualitative and quantitative structure of materials was investigated by IR spectroscopy and thermogravimetric analysis
Summary
The study of free-radical processes of lipid oxidation and antioxidant system is an important problem of modern biomedicine. Metabolic processes produce reactive oxygen species (ROSs), free radicals, peroxides, malonic dialdehyde, Schiff's bases, which damage membrane structures and lead to oxidative stress, being the causative factor for a lot of widely spread diseases, including reproductive disorders and prenatal injuries [1,2,3]. Concerning this the role of antioxidants is to neutralize toxic products of free-radical lipid peroxidation. Various substances are known to have antioxidant activity; their investigation is of certain importance for both biology and medicine [4]
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