Abstract
It is known that humoral factors of immunity play an important function of mediators in the cascade development of the immune response and can determine the effectiveness of the final, effector reactions of cellular immunity in the inactivation and elimination of antigens. Serum concentrations of major immunoglobulins IgG, IgA, IgM in NHL were analyzed. The highest serum content of IgG and IgA was revealed in the groups of patients with virus carrier. It has been established that one of the most important humoral markers of immunity is the circulating immune complexes (CIC). It has been established that one of the most important biological functions of immunoglobulins is antigen binding and the formation of CIC. A high level of CIC in NHL may be due not only to the activation of the immune response, but also to the suppression of the mechanisms of their elimination. Therefore, based on the results obtained, with NHL there is a pronounced imbalance of humoral immunity. CIC of large and small sizes are also increased, however, the highest increase in CIC was observed in groups of patients before chemotherapy with virus-bearing. An increase in the main immunoglobulins indicates the presence of humoral imbalance, and an increase in the CIC indicates the presence of intoxication of the body either due to the decay of the tumor cells themselves and infected cells, which almost always indicates the progression of the pathological process.
Highlights
Despite a significant deepening in the last decade of ideas in the etiology, immunopathogenesis, course and progression of malignant processes, many questions regarding the mechanisms of the development of the pathological process and its course, evaluation of treatment effectiveness, remain open [10,12]
Obtained by analyzing a sufficiently large amount of clinical material that makes it possible to study the frequency of occurrence of various non-Hodgkin’s lymphomas (NHL) variants; comparison of clinical, morphological and immunological data, as well as the results of treatment of T- and B-cell lymphomas, which opens up the possibility of improving the diagnosis and individualization of chemotherapy programs depending on the immunophenotypic characteristics of tumor cells [1,3,8,12]
Based on the foregoing, we evaluated the humoral factors of the immune system in patients with NHL depending on the virus carrier
Summary
Despite a significant deepening in the last decade of ideas in the etiology, immunopathogenesis, course and progression of malignant processes, many questions regarding the mechanisms of the development of the pathological process and its course, evaluation of treatment effectiveness, remain open [10,12]. An important role in the course and effectiveness of therapy for lymphomas belongs to the cellular and humoral factors of the immune system [4,7]. Obtained by analyzing a sufficiently large amount of clinical material that makes it possible to study the frequency of occurrence of various NHL variants; comparison of clinical, morphological and immunological data, as well as the results of treatment of T- and B-cell lymphomas, which opens up the possibility of improving the diagnosis and individualization of chemotherapy programs depending on the immunophenotypic characteristics of tumor cells [1,3,8,12].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
