Abstract
Objective To explore the relationship between High risk human papilloma virus DNA and precancerous cervical diseases and evaluate the clinic value of hybrid capture 2 HC2 . Methods 262 patients who had received thinprep cytologic test TCT, HC2 and colposcopic biopsy in our hospital were analyzed retrospectively. Results Among the 262 patients, the prevalence of high risk HPV infection with normal and cervicitis, CIN Ⅰ , CIN Ⅱ , CIN Ⅲ, cervix cancer were 21. 5% ,66. 7% ,90.0% ,98. 3% , 100% , respectively. No significant difference was found in patients aged among 20 ～ 50 P =0.287. The histology diagnosis was as criteria and atypical squamous cell of undetermined significance ASCUS as a borderline, the sensitivity of HC2, TCT and the combination of the two methods were 89.4% , 53% , 92.4% , and the specificity was 78. 5% , 97.7% , 76. 9% , and positive predictive value was 80.8% ,95. 9% ,80.3% , and negative predictive value was 87. 9% ,67.2% ,90.9%. Conclusion The prevalence of high risk HPV has relationship with precancerous cervical diseases increases along with the severity of CIN. CIN screening would be applied to population of reproductive-age women. High risk HPV test with HC2 is a good method for CIN screening. It's more efficient to find out CIN with the combination of HC2 and TCT. Key words: Papillomavirus; human/IP; Cervix neoplasms/VI/PA; Nucleic acid probes; Polymerase chain reaction/MT
Published Version
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