The study of expression of interleukin-36 and interleukin-36 receptor antagonist IL-36Ra in patients with psoriasis and dinical significance

Abstract

Methods The level of serum IL-36γ, IL-36β, IL-36αand receptor antagonist IL-36Ra was tested by enzyme linked immunosorbent assay (ELISA) in 50 patients with psoriasis vulgaris(PV), 50 patients with generalized pustular psoriasis(GPP) and 50 healthy people. Recruitment occurred between June 2013 to May 2014. The healthy people were admitted into the hospital for physical examination . The levels of serum IL-36 and receptor antagonist IL-36Ra was compared between PV group, GPP group and the control group, and the levels of serum IL-36γ, IL-36β, IL-36αand receptor antagonist IL-36Ra was also compared in patients with different disease severity. Results The level of serum IL-36γ, IL-36β, IL-36αin PV group was significantly higher than those in the control group while the level of receptor antagonist IL-36Ra was lower, and the differences was statistically significant (P<0.05); The level of the serum IL-36γ, IL-36β, IL-36αin GPP group was significantly higher than thosein the control group while the level of receptor antagonist IL-36Ra was lower, and the differences was statistically significant (P<0.05). Meanwhile, the level of IL-36 has significant differences between moderate and severe GPP group and the control group (P<0.05). The comparison of the of IL-36 level between patients with mild PV and patients with severe GPP, and comparison between patients with moderate or severe GPP and mild GPP were statistically significant (P<0.05). Conclusion The level of serum IL-36 and receptor antagonist IL-36Ra are closely related with the severity of psoriasis Key words: Psoriasis; Interleukin-36; Interleukin-36Ra