Abstract

EBV was found to be activated by cocultivation of EBV transformed lymphoblastoid cell lines and a mammary carcinoma cell line, MCF- 7. Both non-EBV producer and producer cell lines are susceptible to this activation. However not every EBV-transformed cell line can be activated. Although the mechanism of activation was investigated in a number of ways, it is still unknown whether the process requires cell to cell contact, if the inducing agent is secreted in the medium and where in the host cell or the virus cycle it acts.

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