Abstract
In this paper, the electrochemical characteristics of methotrexate are studied by using different electrochemical methods at the mercury drop electrode. In Britton-Robinson buffer solution (pH 9.20), a pair of redox peaks of methotrexate controlled by adsorption is obtained by cyclic voltammetry. The differential pulse voltammetry peak currents have a linear relationship with methotrexate concentrations in the range of 1.0 x 10 -5 mol/L ∼ 1.0 x 10 -8 mol/L with a detection limit of 2.0 x 10 -9 mol/L, which has been used in real sample analysis with satisfactory result. Moreover, the electrode reaction mechanism of the system was studied and the kinetic parameters were obtained too. The electrode reduction of MTX is a quasi-reversible process with two electrons and two protons.
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