Abstract
Dengue fever is an acute febrile arboviral disease affecting tropical & subtropical regions of the world. Dengue infection produces a spectrum of clinical illness, ranging from an asymptomatic to its most severe form like dengue haemorrhagic fever and dengue shock syndrome. In view of high morbidity and mortality, it is imperative to have a rapid and sensitive laboratory assay for early detection of the dengue infection. The newer parameter NS1 antigen has gained a lot of interest for early diagnosis of the disease. Detection of non-structural antigen (NS1 Ag), IgM and IgG antibody may help in the early diagnosis. The present study was conducted in a RIMS Adilabad, tertiary care hospital & medical college in the Department of General Medicine. A total of 100 serum samples were processed from suspected cases of dengue fever by using dengue test for detection of NS1 antigen and IgG antibodies. Platelet counts of all these cases were noted. . Of these 100 subjects 85 were serologically proved to have dengue illness, 57 patients were NS1 antigen positive, 28 patients were IgM antibody positive patients. As the NS1 antigen is detectable in blood from day one after onset of fever, its assay is an effective tool for early diagnosis of dengue infection so as to avoid complications.
 Key words: Dengue, NS1 Antigen, IgM antibody, Platelet
Highlights
Dengue virus infection has emerged as a notable public health problem in recent decades in term of the mortality and morbidity associated with it.[1,2] Dengue is endemic in many parts of India and epidemics are frequently reported from various parts of India and abroad[.3,4]Dengue fever is a sever flu like illness that affects the infants, children’s, adolescents, and adults.[5]
Detection of non-structural antigen (NS1 Ag), IgM and IgG antibody may help in the early diagnosis
As the non-structural 1 antigen (NS1) antigen is detectable in blood from day one after onset of fever, its assay is an effective tool for early diagnosis of dengue infection so as to avoid complications
Summary
Dengue virus infection has emerged as a notable public health problem in recent decades in term of the mortality and morbidity associated with it.[1,2] Dengue is endemic in many parts of India and epidemics are frequently reported from various parts of India and abroad[.3,4]Dengue fever is a sever flu like illness that affects the infants, children’s, adolescents, and adults.[5]. The DHF is distinguished from DF by the onset of plasma leakage, marked thrombocytopenia, and a bleeding diathesis.[10,11] In view of high mortality and morbidity rates, it is imperative to have a rapid and sensitive laboratory assay for early detection of the disease. Several laboratory methods such as virus isolation, genomic RNA, antigen and antibody detection methods are available to diagnose the dengue infection (Datta et al, (2010).
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