The Study of Biomarkers of Systemic Inflammation in Patients with Chronic Obstructive Pulmonary Disease in the Relationship with the Severity of Shortness of Breath and Indicators of the Quality of Life of Patients

Abstract

The objective: to study the levels of biomarkers of systemic inflammation (IL-8 and TNF-α) in patients with chronic obstructive pulmonary disease (COPD) in conjunction with the severity of shortness of breath and indicators of the impact of the disease on the quality of life of patients.Materials and methods. The study involved 120 patients with COPD: 115 men and 5 women (average age – 58.5 ± 4.1 years). All patients were active smokers. Patients were hospitalized for exacerbation of COPD in theKharkov city pulmonology center. Diagnosis and treatment of patients is performed in accordance with current clinical protocols.Results. The relationship between the severity of dyspnea and the level of biomarkers of systemic inflammation is characterized by the undulating character of the level of biomarkers of systemic inflammation, which indicates their different pathogenetic significance at the stages of evelopment of COPD.Conclusion. It was revealed that the nature and severity of changes in the levels of biomarkers of systemic inflammation is interrelated with the severity of shortness of breath and indicators of the influence of COPD on the quality of life of patients. An analysis of the relative indices of IL-8 and TNF-α in relation to the degree of dyspnea revealed that with a 2nd degree of severity of dyspnea, an increase (1.5 times) in the content of TNF-α is more informative, and with a 3rd degree, an increase ( 1.4 times) the level of blood levels of IL-8. It was revealed that the increasing influence of COPD on the quality of life of patients is characterized by a stable tendency to an increase in the blood content of IL-8 with a relatively stable level of TNF-α.