The Study of Abnormal Uterine Bleeding, Estrogen And Progesterone Receptor Expression In Cases of Endometrial Hyperplasia And Neoplasia

Abstract

AUB is the very common condition of patients in gynaecological OPD.The aim of study is to evaluate the histopatholological patterns of endometrium and to correlate it with different age groups and study ER and PR receptor expression in them. Meterials and Methods: It is a reterograde study from 1 st jan 2021 to 30th june 2022 in the Department of Pathology ,T S Misra Medical College and Hospital in collaboration with King George’s Medical University. The study includes around 87 patients in the age group 30 to 80 yrs. .All the relevant cinical details and investigations was obtained from patients record.The study includes AUB cases of histopathologicaly diagnosed endometrial pathology .Those cases with inadequate sample or with history of pregnancy was excluded from study.The specimens were routinely processed and Hand E stained slides are studied for endometrial patterns and their frequencies and percentages were classified age group wise.ER and PR positivity percentage was determined in different patterns with immunohistochemistry. Results: Number of patients falling in different age groups were noted and the result concluded was maximum number of AUB cases were in 40 -50 yrs in perimenopausal and post menopausal age group less number was in the reproductive age group Number of patients in different histopathological pattern was also noted. Endometrial patterns included non malignant( 65/87,) proliferative (%) followed by secretary (%) and endometrial hyperplasia without atypia( %),simple hyperplasia with atypia (%) ,complex hyperplasia with atypia (%) and malignant(22/87)endometrial carcinoma (25.3%). ER and PR positivity rate was 95.4% and 96.6% respectively in whole study. ER and PR expression in each pattern was also studied. Conclusion; Histopathological examination plays a critical role in early diagnosis of endometrial pathology and to plan appropriate gynaecological management. Knowledge of ER ,PR expression is helpful in determining the prognosis for survival and hormone replacement therapy.