Abstract
目的 探讨非甾体抗炎药在小儿全身炎症反应综合征(SIRS)治疗中的作用及其可能的机制,以期为临床诊治SIRS提供新的措施.方法 选择2004年1月～12月住院的SIRS患儿40例,依据治疗措施分为常规治疗组20例和布洛芬干预组20例,采用免疫化学发光法、酶联免疫吸附测定法检测SIRS患儿治疗前后血清中降钙素原(PCT)、TNF-α、IL-1β、IL-10水平,观察应用非甾体抗炎药后的临床资料及PCT与上述细胞因子水平的变化.结果 布洛芬干预组治疗后,血清PCT水平较常规治疗组降低,但差异无显著性(P＞0.05);血清TNF-α水平明显下降(P＜0.01);血清IL-1β及血清IL-10水平下降程度大于常规治疗组,差异无显著性(P＞0.05);治疗后的临床疗效同常规治疗组比较差异无显著性(P＞0.05).结论 非甾体抗炎药(布洛芬)可降低SIRS患儿血清中重要致炎因子TNF-α水平,并使PCT、IL-1β、IL-10水平呈下降趋势,提示非甾体抗炎药可能抑制炎症因子的释放,进而缓解因炎症因子聚集引起的炎症反应,从而达到治疗SIRS的目的。
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