Abstract
In 1986, Rita Levi-Montalcini and Stanley Cohen were awarded with the Nobel Prize for Physiology and Medicine for the discovery of the nerve growth factor. Among the experimental models used by Levi-Montalcini in the first part of her studies it was the chick embryo chorioallantoic membrane, currently used in the study of tumor growth and angiogenesis. Levi-Montalcini grafted fragments of mouse sarcomas on to the chorioallantoic membranes of 4- to 6-day chick embryos and demonstrated that the tumors infiltrated the host blood vessels. Moreover, the ganglia showed hypertrophy, nerve fibers reaching to the implanted tumors. Levi-Montalcini hypothesized that the effects could have been mediated by a soluble factor, which was later identified as the nerve growth factor.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
