The structure\u2013function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa

Ching-Wen Huang,Tzyy-Chang Ho,Chang-Hao Yang,Fung-Rong Hu,Chung-May Yang,Ta-Ching Chen,Jung-Je Yang

doi:10.1038/s41598-021-96570-7

Ching-Wen Huang, Tzyy-Chang Ho + Show 5 more

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https://doi.org/10.1038/s41598-021-96570-7

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Abstract

To investigate the structure–function correlation analysed by full-field electroretinography (ffERG) and optical coherence tomography (OCT) in typical and pericentral subtypes of retinitis pigmentosa (RP). A retrospective, cross-sectional, observational study of right eyes was conducted. The primary analysis used ffERG data to compare the RP subtypes. The subgroup analysis was used to correlate the structure, analysed by OCT, and function, determined by ffERG. Linear regressions explored the relationship between best-corrected visual acuity (BCVA) and multiple parameters. A total of 188 eyes were included. Amplitudes of responses of rod, rod-cone, cone, and 30 Hz flicker of typical type were lower than those of pericentral and other types. In the subgroup analysis, 41 and 21 eyes of the typical and pericentral types were studied, respectively. The correlation between the estimated preserved photoreceptor area and all ffERG amplitude parameters were significant in the typical type, but not in pericentral type. Old age, decreased intact ellipsoid zone length, typical type, and thin central retinal thickness were negatively correlated with BCVA. Typical type RP developed more extensive degeneration and poorer BCVA compared to others. Strong structure–function correlation was found in typical type while not in pericentral type. OCT may be a useful tool for monitoring RP status in typical type, providing useful parameters for the prediction of BCVA.

Highlights

Retinitis pigmentosa (RP) is an inherited disease characterised by the progressive loss of rods followed by c ones[1]
optical coherence tomography (OCT) allows analysis of many parameters, including the residual ellipsoid zone (EZ) length[7,8,9], preserved photoreceptor area[5], and central retinal thickness (CRT)[10,11], which are correlated to visual acuity (VA)
retinitis pigmentosa (RP) is a heterogeneous disease in terms of both genotypes and phenotypes

Summary

Introduction

Retinitis pigmentosa (RP) is an inherited disease characterised by the progressive loss of rods followed by c ones[1]. Several diagnostic tools, including visual field testing, optical coherence tomography (OCT), fullfield electroretinogram (ffERG), multifocal electroretinogram (mfERG), microperimetry, and autofluorescence imaging, can be used to evaluate the progression of RP2. OCT allows analysis of many parameters, including the residual ellipsoid zone (EZ) length[7,8,9], preserved photoreceptor area[5], and central retinal thickness (CRT)[10,11], which are correlated to visual acuity (VA). The T type has characteristic lesions originating from the far periphery and gradually extending to the central area of the retina. The clinical characteristic of the P type is that the lesions mainly affect the surrounding area of the major temporal arcade on the retina, while the far periphery is relatively spared. The other was to correlate the functional and structural parameters in the different subtypes of RP

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