The structure and replication of rhinoviruses.

Abstract

Human rhinoviruses are a major cause of mild upper respiratory tract infections in man. Early work on the isolation, propagation and characterisation of these viruses in organ and tissue culture has been extensively reviewed (Andrewes 1966; Hamre 1968; Tyrrell 1968; Jackson and Muldoon 1973; Gwaltney 1975). Numerous studies have also been done on the epidemiology of the spread of rhinovirus infections and their route of transmission. Much of this work has been described by Gwaltney (1975). Bovine and equine rhinoviruses have also been isolated, and generally these viruses also produce respiratory tract infections in their hosts (Stott and Killington 1972; Jackson and Muldoon 1973; Butterworth et al. 1976). Comprehensive reviews on the structure (Stott and Killington 1972) and replication (Stott and Killington 1972; Butterworth et al. 1976) of rhinoviruses have already been published, and in this review recent studies on the classification, structure and antigenicity of the virus particle, and its replication in host cells, are considered.KeywordsVirus ParticleBuoyant DensityHuman RhinovirusEmpty CapsidImmune Electron MicroscopyThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.