Abstract
In present investigation new formulations of Sodium Alginate/Acrylic acid hydrogels with high porous structure were synthesized by free radical polymerization technique for the controlled drug delivery of analgesic agent to colon. Many structural parameters like molecular weight between crosslinks (Mc), crosslink density (Mr), volume interaction parameter (v2,s), Flory Huggins water interaction parameter and diffusion coefficient (Q) were calculated. Water uptake studies was conducted in different USP phosphate buffer solutions. All samples showed higher swelling ratio with increasing pH values because of ionization of carboxylic groups at higher pH values. Porosity and gel fraction of all the samples were calculated. New selected samples were loaded with the model drug (diclofenac potassium).The amount of drug loaded and released was determined and it was found that all the samples showed higher release of drug at higher pH values. Release of diclofenac potassium was found to be dependent on the ratio of sodium alginate/acrylic acid, EGDMA and pH of the medium. Experimental data was fitted to various model equations and corresponding parameters were calculated to study the release mechanism. The Structural, Morphological and Thermal Properties of interpenetrating hydrogels were studied by FTIR, XRD, DSC, and SEM.
Highlights
Drug delivery systems (DDS) improve the administration and efficacy of pharmaceutical compounds including antibodies, peptides, vaccines, drugs and enzymes
In present work pH sensitive highly porous cross-linked sodium alginate/acrylic acid (NaAlg/Acrylic acid (AA)) hydrogels were prepared by free radical polymerization using ethylene glycol dimethacrylate (EGDMA) as crosslinking agent as a carrier for water soluble drugs
The swelling ratio decreased with the increased concentration of monomer (AA) and cross linker (EGDMA) while increases with increasing concentration of polymer (NaAlg)
Summary
Drug delivery systems (DDS) improve the administration and efficacy of pharmaceutical compounds including antibodies, peptides, vaccines, drugs and enzymes. The swelling procedure was continued in order to estimate the equilibrium proportion of the hydrogels and final calculation is obtained when the weight of the disc become constant. The gels were collected from the apparatus first dried at room temperature and at 45 °C in the oven until their weight became constant.[30] The gel fraction of the samples was calculated by employing following formula. In the third method the amount of drug loaded in the hydrogel is calculated by measuring the weight of the gel in its equilibrium swelling state. Drug release was calculated by measuring the dissolution in dissolution apparatus (Pharma test; PT-Dt 7) and with UV–Vis spectrophotometer (Perkin Elmer Lambda 25).The weighted hydrogel disc was placed in 900 ml dissolution medium at 37 °C and dissolution medium was set at a rate of 100 rpm for maintaining a uniform drug concentration in the medium. For the statistical analysis of data, Student’s t-test has been applied to compare the results and to determine the statistical significant/non-significant interpretation at 95% confidence interval, p-value less than 0.05 was considered as significant difference in results
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